folinic acid-responsive seizures true UMLS:CN205780 MONDO:0019197 Folinic acid responsive seizures This metabolic disorder is an allelic condition to pyridoxine dependent epilepsy with similar biochemical markers. Individuals may have a partial pyridoxine response, then may require co-therapy with folinic acid. Research is underway into the mechanism for folinic acid response. In CSF studies of biogenic amines, an unknown peak (peak X) is seen. Editor note: TODO request from CHEBI ICD10:G40.3 Orphanet:79097 SCTID:717276003 Folinic acid-responsive seizures is a very rare neonatal epileptic encephalopathy disorder characterized clinically by myoclonic and clonic, or clonic seizures associated with apnea occurring several hours to 5 days after birth and responding to folinic acid. metabolic etiology