anti-NMDA receptor encephalitis true MESH:D060426 An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor. MONDO:0021081 Antibodies are directed against the NR1 subunit of the NMDA receptor. Clinical manifestations typically include: A prodrome, this may last several weeks, symptoms include fever, headache, nausea, vomiting and diarrhea , A symptomatic phase, symptoms may include all of the following: Psychiatric and behavioral symptoms: anxiety, bizarre behavior, delirium, paranoia , Insomnia or hypersomnia, Altered level of consciousness Seizures (focal or generalized) , Movement disorders: oral-motor dyskinesias, choreiform movements , Hypoventilation, Autonomic instability: incontinence, tachycardia, hypertension, hyperthermia NCIT:C94853 anti-NMDA receptor encephalitis antibody mediated epilepsy