Gene Abnormality true Genetic Mutation Current knowledge regarding the contribution of gene abnormalities to epilepsy derives from specific molecular genetic studies that have been well replicated and even become the basis of diagnostic testing, or from appropriately designed family studies. C36327 Gene_Abnormality Gene Abnormality A variation in or modification of the nucleic acid sequence of a gene that can alter its expression and may result in either a congenital disorder or the clinical presentation of a disease. C1517478 Gene Abnormality http://www.case.edu/EpSO.owl#GeneticMutation Cell or Molecular Dysfunction genetic etiology