Malformations of Cortical Development true Malformations of Cortical Development C1955869 C84834 A group of neural cortical developmental malformations of diverse genetic causes. Clinical manifestations include epilepsy and developmental delays. Malformations of Cortical Development Congenital Abnormality Malformations of cortical development are structural abnormalities of the cerebral cortex (the grey matter that lines the surface of the brain), which arise due to the abnormal formation of the cerebral cortex in early (intrauterine) life. The precursor cells of the cerebral cortex are initially formed in the periventricular region, and then migrate to their correct location to form the normal structure and cell connections seen in the mature cerebral cortex. structural etiology