In Vitro Model calcium-activated potassium channel model true https://www.ncbi.nlm.nih.gov/pubmed/29623857 Potassium channels are activated by the increase of the intracellular Ca2+ concentration, a consequence of neuronal excitation, and then terminate the action potential with the outward K+ flux and precludes excessive Ca2+ influx. Considering this negative feedback effect, BK channel seemly acts to decrease membrane excitability in order to prevent hyperexcitation which is a typical characteristic of epilepsy. modified definition