Kindling model hippocampal kindling model true https://www.ncbi.nlm.nih.gov/pubmed/27070861 Hippocampal kindling models are animal models, where there is a progressive increase in electrographic and behavioral seizure activity in response to repeated stimulation of a limbic brain region such as hippocampus with an initially subconvulsive current. Kindling is associated with a progressive increase in seizure severity and duration, a decrease in focal seizure threshold, and neuronal degeneration in limbic brain regions that resemble human temporal lobe epilepsy Modified definition