seizure insular lobe seizure true https://www.ncbi.nlm.nih.gov/pubmed/15329073 Seizures that arise from any part of the insula and frequently spread to adjacent medial opercular regions which share some functional commonalities with the insula. The best example is the painful seizure, where the ictal discharges often involve the posterior insula as well as the medial parietal operculum and such functional commonality is well supported by the neurophysiological evidence. Therefore, it is often more accurate to describe these as insulo-opercular seizures, rather than strictly insular seizures.