lamotrigine resistant kindled model true The LTG-resistant kindled model is one of the most recently and widely investigated for the kindling process and drug resistance. The kindling process depicts epileptogenesis that could be achieved from stimulation either by a low-intensity electric current at the amygdala or by the administration of a subconvulsive dose of a CNS stimulant such as pentylenetetrazole (PTZ), picrotoxin or strychnine once daily or every other day over a period of time to induce a permanent alteration in the epileptogenic sensitivity of the brain LTG-resistant kindled model pharmacoresistant epilepsy model