convulsant drug model lithium-pilocarpine model true Modified definition https://www.ncbi.nlm.nih.gov/pubmed/1324090 In this model, lithium is used to potentiate the ability of pilocarpine to induce status epilepticus in rats. Lithium followed by pilocarpine, induced hyperactivity, tremor, loss of postural control and scratching but no electrographic seizures in rats.