infectious cause of seizure malaria-related seizure true Malaria-associated seizures (MAS) can occur within two settings, either as isolated seizures within the setting of fever or in the setting of cerebral malaria. In cerebral malaria, other severe neurological symptoms such as coma and cerebral edema are observed, which are probably due to impaired capillary perfusion. In cerebral malaria, seizures can also occur without fever.