Rodent Model of Disease neonatal hypoxia model true Modified definition In this model neonatal animals were exposed to graded global hypoxia to develop spontaneous seizures later in life, as well as mossy fiber sprouting and long-term behavioral alterations, including social deficits, memory impairments, and aggressiveness. Despite the lack of early neuronal injury, hypoxia-induced seizures promote hyperexcitability immediately after seizure recovery, facilitating long-term potentiation induction and generating longer ADs. Increased excitability persists in the adult hippocampus, suggesting that the epileptogenic effects of hypoxia are mediated by permanent effects on excitability and plasticity within hippocampal networks. https://www.ncbi.nlm.nih.gov/pubmed/25228809