convulsant drug model zinc model true Elevated concentrations of zinc (Zn2+) (>100 mM) may contribute to neuronal cell death during, seizures, Seizures produced by the intracerebral injection of zinc sulphate (ZnSO4) have proven that it is a convulsant capable of inducing an experimental model of chronic epilepsy; when 600 pg/kg of ZnSO4 are applied via intracerebral injection to experimental animals, typical clonic seizures are observed