antibody mediated epilepsy
voltage-gated potassium channel antibody
true
Antibodies directed against the voltage gated potassium channels bind to other proteins including LGI1 (leucine-rich, glioma-inactivated 1 protein) and CASPR2 (contactin-associated protein 2) resulting in a complex antibody. These antibodies cause limbic encephalitis with the following common features:
Short term memory loss
Intractable focal seizures with a high frequency, these commonly have temporal lobe features; however focal sensory olfactory seizures or focal autonomic seizures with piloerection (with shivering phenomena) are distinctive seizure types in this etiology
Focal motor seizures with dystonia in face and arm (brief episodes of unilateral facial grimace and arm posturing) - these are characteristic of antibody to LGI1
Hyponatremia
Dysautonomia
Sleep disturbance
Psychiatric symptoms