part of presumptive embryonic/larval central nervous system developing embryonic structure Notch OFF hemilineage primary neuron NB5-3 lineage primary neuron immature primary neuron embryonic immature Va neurosecretory neuron 2025-01-24T14:42:55Z Immature neuron in the developing VNC of the embryo that is derived from neuroblast NB5-3 and has a ventral soma (Suska et al., 2011; Gabilondo et al., 2011; Gabilondo et al., 2018). It is a Notch OFF neuron and its sibling Notch on cell dies by apoptosis (Gabilondo et al., 2011). In segments A1-A4, these cells develop into neurosecretory cells (Suska et al., 2011; Gabilondo et al., 2018). More posterior neurons undergo apoptosis prior to stage 16 (Suska et al., 2011; Gabilondo et al., 2011). In thoracic segments, they do not acquire a neurosecretory fate (Suska et al., 2011). fly_anatomy.ontology Gabilondo et al. (2011) only show Capa+ A2-A7 neurons. Gabilondo et al. (2018) additionally show A1 Va neuron in NB5-3 lineage. Suska et al. (2011) show Dac+/Dimm+ cells in A8 and Dimm+ in T1-3 in same position as Va and refer to these as 'Va'. They do not directly demonstrate developmental origin, but A8 neurons survive and produce Capa in Abd-B mutants, suggesting Va identity. Gabilondo et al. (2018) could transform thoracic neurons into AstA+/Dh31+ cells with Ubx expression, also suggesting Va identity. FBbt:00053351 VFB:FBbt_00053351