has soma location capable of expresses sends synaptic output to region has sensory dendrite in Ir21a dorsal organ base sensillum embryonic/larval antennal lobe glomerulus dorsal organ ganglion dorsal organ cool cell FBbt:00047145 larval thermo-cold sensory neuron Ir21a, Ir25a and Ir93a -expressing neuron of the dorsal organ ganglion (DOG), activated by temperature decreases (Klein et al., 2015; Ni et al., 2016; Knecht et al., 2016). All three of these Ir genes are necessary for cold-induced activity of these cells (Knecht et al., 2016), with Ir21a specifying cooling, rather than warming sensitivity (Hernandez-Nunez et al., 2021). Three of these cells are found in each DOG and they are required for cold avoidance behavior (Klein et al., 2015). The sensory dendrites of these neurons exhibit membrane infoldings and lamellae in the base of the dorsal organ and they do not reach the central dome (Klein et al., 2015; Hernandez-Nunez et al., 2021). They project to an antennal lobe glomerulus posterior and slightly dorsal to the olfactory glomeruli (Klein et al., 2015; Hernandez-Nunez et al., 2021). DOCC VFB:FBbt_00047145 larval cooling cell larval CC fly_anatomy.ontology dorsal organ sensory neuron larval thermosensory neuron detection of cold stimulus involved in thermoception