macrolide antibiotic polyene antibiotic epoxide dicarboxylic acid monoester monosaccharide derivative natamycin Codex::235 A macrolide antibiotic that has formula C<small>₃₃</small>H<small>₄₇</small>NO<small>₁₃</small>, produced by several <em>Streptomyces</em> species including <em>Streptomyces natalensis</em>. It exhibits broad spectrum antifungal activity and used in eye drops, and as a food preservative, and also as a postharvest biofungicide for citrus and other fruit crops. Europe::235 LanguaL term definition: Food additive; technological purpose(s): preservative. natamycin (pimaricin) antibiotic antifungal drug food additive