midwestern states State of Minnesota A state in the Midwestern region of the United States. The state shares a Lake Superior water border with Michigan and Wisconsin on the northeast; the remainder of the eastern border is with Wisconsin. Iowa is to the south, North Dakota and South Dakota to the west, and the Canadian provinces of Ontario and Manitoba to the north. LanguaL curation note: US FDA 1995 Code: US27 minnesota State of Minnesota A state in the Midwestern region of the United States. The state shares a Lake Superior water border with Michigan and Wisconsin on the northeast; the remainder of the eastern border is with Wisconsin. Iowa is to the south, North Dakota and South Dakota to the west, and the Canadian provinces of Ontario and Manitoba to the north. LanguaL curation note: US FDA 1995 Code: US27 minnesota