middle atlantic states State of West Virginia A state in the Appalachian, Upland South, and Mid-Atlantic regions of the United States, bordered by Virginia on the southeast, Kentucky on the southwest, Ohio on the northwest, and Pennsylvania and Maryland on the northeast. The capital and largest city is Charleston. LanguaL curation note: US FDA 1995 Code: US54 west virginia State of West Virginia A state in the Appalachian, Upland South, and Mid-Atlantic regions of the United States, bordered by Virginia on the southeast, Kentucky on the southwest, Ohio on the northwest, and Pennsylvania and Maryland on the northeast. The capital and largest city is Charleston. LanguaL curation note: US FDA 1995 Code: US54 west virginia