southeastern states State of Mississippi A state located in the Deep South of the United States. Jackson is the state capital and largest city. Mississippi is bordered on the north by Tennessee, on the east by Alabama, on the south by Louisiana and a narrow coast on the Gulf of Mexico, and on the west, across the Mississippi River, by Louisiana and Arkansas. LanguaL curation note: US FDA 1995 Code: US28 mississippi State of Mississippi A state located in the Deep South of the United States. Jackson is the state capital and largest city. Mississippi is bordered on the north by Tennessee, on the east by Alabama, on the south by Louisiana and a narrow coast on the Gulf of Mexico, and on the west, across the Mississippi River, by Louisiana and Arkansas. LanguaL curation note: US FDA 1995 Code: US28 mississippi