middle atlantic states Commonwealth of Kentucky A state located in the East Central United States of America. Kentucky borders on seven states, from both the Midwest and the Southeast. West Virginia lies to the east, Virginia to the southeast, Tennessee to the south, Missouri to the west, Illinois and Indiana to the northwest, and Ohio to the north and northeast. LanguaL curation note: US FDA 1995 Code: US21 kentucky Commonwealth of Kentucky A state located in the East Central United States of America. Kentucky borders on seven states, from both the Midwest and the Southeast. West Virginia lies to the east, Virginia to the southeast, Tennessee to the south, Missouri to the west, Illinois and Indiana to the northwest, and Ohio to the north and northeast. LanguaL curation note: US FDA 1995 Code: US21 kentucky