negative regulation of gene expression epigenetic regulation of gene expression negative regulation of gene expression, epigenetic https://github.com/geneontology/go-ontology/issues/22201 https://github.com/geneontology/go-ontology/issues/30601 An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. Reactome:R-HSA-5250941 Reactome:R-HSA-212300 down-regulation of gene expression, epigenetic gene silencing downregulation of gene expression, epigenetic down regulation of gene expression, epigenetic inhibition of gene expression, epigenetic GO:0045814