in taxon results in maturation of developmental maturation dense core granule secretory granule maturation dense core granule maturation Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. dense core vesicle maturation kmv 2014-09-30T20:35:11Z GO:1990502