output of output of peptide translation protein PR:000000001 antithrombin III is a protein protein natural protein Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Note also that the definition excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to PR:000064867 ("protein-containing molecular entity"). Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB). An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. native protein An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. amino acid chain protein-containing molecular entity