has role has role TOP-53 chebi_ontology TOP 53 A furonaphthodioxole that is 4'-demethyldeoxypodophyllotoxin which is substituted at position 4 of the C-ring by a 2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl group. While structurally related to etoposide, TOP-53 is significantly more toxic to non-small cell lung cancer cells, more active at generating chromosomal breaks, and displays improved cellular uptake and pharmacokinetics in animal lung tissues. 4'-demethyl-4beta-(2-{N-[2-(N',N'-dimethylamino)ethyl]-N-methylamino}ethyl)-4-desoxypodophyllotoxin CHEBI:134547 phenols antineoplastic agent gamma-lactone furonaphthodioxole EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor tertiary amino compound