has role has role is conjugate base of is deprotonated form of ether organofluorine compound anti-arrhythmia drug N-alkylpiperazine dopamine uptake inhibitor vanoxerine(2+) vanoxerine GBR 12909 CHEBI:64089 GBR12909 chebi_ontology An <em>N</em>-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC<small>₅₀</small> = 48 nM). Centrally active following systemic administration.