abnormal regulation of mitotic DNA replication initiation increased origin firing efficiency increased origin firing efficiency during mitotic cell cycle midori increased origin firing efficiency during vegetative growth 2012-07-17T13:28:55Z A regulation phenotype observed in the vegetative growth phase of the life cycle in which the probability that a DNA replication will initiate at a particular replication origin is higher than in wild type. In cells with increased origin firing efficiency, genomic DNA replication initiates from more origins than wild type, and is completed in more, smaller segments, than wild type. FYPO:0001249