abnormal regulation of mitotic DNA replication initiation decreased origin firing efficiency decreased origin firing efficiency during mitotic cell cycle reduced origin firing efficiency A regulation phenotype observed in the vegetative growth phase of the life cycle in which the probability that a DNA replication will initiate at a particular replication origin is lower than in wild type. In cells with decreased origin firing efficiency, genomic DNA replication initiates from fewer origins than wild type, and is completed in fewer, larger segments, than wild type. midori FYPO:0001250 decreased origin firing efficiency during vegetative growth 2012-07-17T13:31:48Z