normal vegetative phenotype normal minichromosome loss A cell phenotype in which minichromosomes are lost at the same frequency as in wild-type cells. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'normal plasmid loss' (FYPO:0001790). midori FYPO:0001839 2012-12-06T16:04:43Z