output_of abnormal meiotic chromosome segregation increased minichromosome loss during meiotic cell cycle increased minichromosome loss upon segregation during meiotic cell cycle meiotic minichromosome maintenance defect 2012-12-18T14:55:41Z Use this term if the assay to detect minichromosome loss can distinguish a segregation defect from a replication defect (e.g. by microscopy). Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786). FYPO:0001862 midori increased plasmid loss upon segregation during meiosis A cell phenotype in which minichromosomes are lost due to abnormal meiotic chromosome segregation at a higher frequency than normal.