abnormal cellular process during vegetative growth abnormal spatio-temporal regulation of replication fork localization abnormal replication foci dynamics A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the spatio-temporal pattern of localization of replication forks into nuclear foci is abnormal. Normally, replication forks appear organized into foci outside the nucleolus in early S phase. As S phase progresses, the number of foci first increases, then decreases, and the remaining foci concentrate within the nucleolus or at the nucleolar periphery. The last replication foci remaining at the end of S phase are one or two large spots at the nucleolar border. abnormal replication focus organization abnormal spatio-temporal regulation of replication fork localization during vegetative growth abnormal spatio-temporal regulation of replication fork localization during mitotic cell cycle abnormal spatio-temporal replication fork organization midori 2015-12-18T14:14:47Z abnormal spatio-temporal regulation of replication fork localisation FYPO:0005165