L-glutamate dehydrogenase [NAD(P)+] activity L-glutamate dehydrogenase (NADP+) activity EC:1.4.1.4 NAD(P)-glutamate dehydrogenase activity L-glutamate dehydrogenase dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) L-glutamic acid dehydrogenase activity NAD(P)H-dependent glutamate dehydrogenase activity MetaCyc:GLUTDEHYD-RXN glutamic acid dehydrogenase Catalysis of the reaction: L-glutamate + NADP+ + H2O = 2-oxoglutarate + NH4+ + NADPH + H+. L-glutamate:NADP+ oxidoreductase (deaminating) GO:0004354 glutamic dehydrogenase activity RHEA:11612 molecular_function