protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
https://github.com/geneontology/go-ontology/issues/25798
protein geranylgeranyltransferase type I
GO:0004662
geranylgeranyltransferase type I activity
GGTaseI activity
MetaCyc:RXN-3701
EC:2.5.1.59
type I protein geranyl-geranyltransferase activity
GGTase-I activity
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
molecular_function