norfloxacin CHEBI:7629 A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase. quinolone quinolinemonocarboxylic acid N-arylpiperazine quinolone antibiotic fluoroquinolone antibiotic