monocarboxylic acid amide pyrazines pyrazinecarboxamide A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. CHEBI:45281 Pza CHEBI:8656 pyrazinamide N-acylammonia first line tuberculosis drug