Thoracic Disorder Non-Neoplastic Thoracic Disorder Non-Neoplastic Thoracic Disorder A non-neoplastic disorder that affects the thorax and/or the organs of the thoracic cavity. Representative examples include pleural infection, mediastinitis, pneumonia, and chronic obstructive pulmonary disease. Non-Neoplastic Thoracic Disease Non-Neoplastic Disorder by Site