nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Wikipedia:Nonsense-mediated_mRNA_decay Reactome:R-HSA-927802 mRNA catabolic process, nonsense-mediated GO:0000184 nuclear mRNA catabolic process, nonsense-mediated decay nonsense-mediated mRNA decay Wikipedia:Nonsense-mediated_decay mRNA degradation, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. biological_process mRNA breakdown, nonsense-mediated decay mRNA catabolism, nonsense-mediated nuclear-transcribed mRNA catabolic process