C-22 sterol desaturase (NADPH) activity https://github.com/geneontology/go-ontology/issues/27381 GO:0000249 RHEA:33467 molecular_function MetaCyc:RXN3O-227 EC:1.14.19.41 RHEA:46576 Catalysis of the reaction: 5-dehydroepisterol + H+ + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP+. This reaction is the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. Also converts sitosterol and 24-epi-campesterol to stigmasterol and brassicasterol, respectively. sterol desaturase activity