Prp19 complex https://github.com/geneontology/go-ontology/issues/26661 krc NTC A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. nineteen complex 2009-10-12T10:01:30Z Prp19/CDC5 complex cellular_component GO:0000974 MOS4-Associated Complex protein-containing complex