transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding https://github.com/geneontology/go-ontology/issues/19312 GO:0000977 2010-08-10T11:05:36Z RNA polymerase II regulatory region DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. GO:0001012 To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. molecular_function krc