adaptive immune response adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains biological_process adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains adaptive immune response in jawless fish GO:0002459 An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae). adaptive immune response based on somatic recombination of VLR built from LRR domains