obsolete generation of a signal involved in cell-cell signaling true This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling. formation of a signal OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal. signal generation GO:0003001 generation of a signal involved in cell-cell signaling biological_process generation of a signal involved in cell-cell signalling cell-cell signaling intercellular transport signal release