transcription coregulator activity https://github.com/geneontology/go-ontology/issues/15536 https://github.com/geneontology/go-ontology/issues/15665 https://github.com/geneontology/go-ontology/issues/15998 https://github.com/geneontology/go-ontology/issues/20253 https://github.com/geneontology/go-ontology/issues/20464 https://github.com/geneontology/go-ontology/issues/20862 https://github.com/geneontology/go-ontology/issues/20962 https://github.com/geneontology/go-ontology/issues/26489 https://github.com/geneontology/go-ontology/issues/28926 https://github.com/geneontology/go-ontology/issues/31471 Reactome:R-HSA-5340251 molecular_function krc GO:0003712 GO:0016455 A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. transcriptional co-regulator Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity. GO:0001104 RNA polymerase II transcriptional cofactor activity transcription cofactor activity 2010-11-24T03:02:15Z nuclear receptor coreceptor activity transcription coreceptor activity transcription regulator activity