part of transcription coregulator activity transcription coactivator activity https://github.com/geneontology/go-ontology/issues/15665 https://github.com/geneontology/go-ontology/issues/15998 https://github.com/geneontology/go-ontology/issues/20253 https://github.com/geneontology/go-ontology/issues/20464 https://github.com/geneontology/go-ontology/issues/28926 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. krc RNA polymerase II transcription co-activator activity 2010-11-24T03:08:19Z RNA polymerase II transcription coactivator activity GO:0001105 GO:0003713 molecular_function RNA polymerase II transcription mediator activity transcription co-activator activity positive regulation of DNA-templated transcription