part of transcription coregulator activity transcription corepressor activity https://github.com/geneontology/go-ontology/issues/15665 https://github.com/geneontology/go-ontology/issues/15998 https://github.com/geneontology/go-ontology/issues/20464 https://github.com/geneontology/go-ontology/issues/28926 RNA polymerase II transcription corepressor activity transcription co-repressor activity RNA polymerase II transcription co-repressor activity krc GO:0003714 Reactome:R-HSA-400183 2010-11-24T03:14:44Z A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. GO:0001106 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. molecular_function negative regulation of DNA-templated transcription