DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity https://github.com/geneontology/go-ontology/issues/15575 https://github.com/geneontology/go-ontology/issues/17661 https://github.com/geneontology/go-ontology/issues/30193 type II DNA topoisomerase activity DNA topoisomerase (ATP-hydrolysing) Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. deoxyribonucleate topoisomerase Wikipedia:Type_II_topoisomerase topoisomerase DNA topoisomerase IV activity topoisomerase II EC:5.6.2.2 DNA topoisomerase type II activity DNA topoisomerase II MetaCyc:5.99.1.3-RXN DNA topoisomerase II activity molecular_function GO:0061505 deoxyribonucleic topoisomerase activity GO:0003918 ATP-dependent activity, acting on DNA