acyl-CoA oxidase activity https://github.com/geneontology/go-ontology/issues/28733 https://github.com/geneontology/go-ontology/issues/30193 Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2. RHEA:66220 GO:0003997 Reactome:R-HSA-193369 RHEA:66224 acyl-CoA:oxygen 2-oxidoreductase activity RHEA:66228 RHEA:66232 Reactome:R-HSA-2066787 molecular_function Reactome:R-HSA-390256 RHEA:66236 fatty acyl-coenzyme A oxidase activity RHEA:38959 RHEA:67212 RHEA:40471 fatty acyl-CoA oxidase activity RHEA:40271 RHEA:39087 RHEA:40315 Reactome:R-HSA-192335 RHEA:40275 RHEA:66208 acyl coenzyme A oxidase activity MetaCyc:RXN-11026 RHEA:39071 RHEA:22952 EC:1.3.3.6 RHEA:66212 RHEA:66216 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor