adenylate cyclase activity https://github.com/geneontology/go-ontology/issues/30193 cAMP generating peptide activity EC:4.6.1.1 adenyl cyclase activity Reactome:R-HSA-9712183 3',5'-cyclic AMP synthetase activity GO:0004016 MetaCyc:ADENYLATECYC-RXN adenylylcyclase activity Reactome:R-HSA-381607 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. molecular_function ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity adenylyl cyclase activity RHEA:15389 Reactome:R-HSA-170676 Reactome:R-HSA-164377 Reactome:R-HSA-5211224 ATP pyrophosphate-lyase activity Reactome:R-HSA-392129 Reactome:R-HSA-5610727 ATP diphosphate-lyase (cyclizing) activity cyclase activity phosphorus-oxygen lyase activity