carboxypeptidase activity metallocarboxypeptidase activity https://github.com/geneontology/go-ontology/issues/19681 EC:3.4.17.1 EC:3.4.17.3 EC:3.4.17.2 EC:3.4.17.4 EC:3.4.17.6 MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN Reactome:R-HSA-9944488 Reactome:R-HSA-9023163 Reactome:R-HSA-2028294 EC:3.4.17.10 Reactome:R-HSA-9023159 Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004181 molecular_function MetaCyc:CARBOXYPEPTIDASE-A-RXN Reactome:R-HSA-8866105 Reactome:R-HSA-8852809 EC:3.4.17.16 Reactome:R-HSA-8955712 EC:3.4.17.22 EC:3.4.17.21 MetaCyc:3.4.17.17-RXN Reactome:R-HSA-2022378 Reactome:R-HSA-2022379 EC:3.4.17.- metalloexopeptidase activity