endopeptidase activity aspartic-type endopeptidase activity https://github.com/geneontology/go-ontology/issues/20581 https://github.com/geneontology/go-ontology/issues/30193 Reactome:R-HSA-2022403 MetaCyc:3.4.23.43-RXN EC:3.4.23.32 EC:3.4.23.35 EC:3.4.23.34 Reactome:R-HSA-9017817 EC:3.4.23.36 Reactome:R-HSA-373705 aspartic protease activity GO:0004190 MetaCyc:3.4.23.4-RXN aspartate protease activity Reactome:R-HSA-9013361 molecular_function EC:3.4.23.20 EC:3.4.23.25 MetaCyc:3.4.23.1-RXN MetaCyc:3.4.23.20-RXN aspartyl protease activity carboxyl protease activity Reactome:R-HSA-157353 EC:3.4.23.- MetaCyc:3.4.23.34-RXN MetaCyc:3.4.23.35-RXN EC:3.4.23.1 aspartic endopeptidase activity EC:3.4.23.4 EC:3.4.23.5 Reactome:R-HSA-2065357 Reactome:R-HSA-9604294 EC:3.4.23.15 Reactome:R-HSA-2220988 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. MetaCyc:3.4.23.15-RXN Reactome:R-HSA-2022412 MetaCyc:3.4.23.5-RXN Reactome:R-HSA-157640 MetaCyc:3.4.23.32-RXN EC:3.4.23.43 EC:3.4.23.49 MetaCyc:3.4.23.25-RXN aspartic-type peptidase activity