cysteine-type endopeptidase activity obsolete caspase-3 activity true GO:0004208 This term was made obsolete because it represents a gene product. OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis. caspase-3 activity molecular_function